4th State MedicalRegenerative · Technology
SCCM Topical Portfolio

Regenerative biosignals, formulated for topical application.

BioSignal's platform harnesses Stem Cell Conditioned Media (SCCM) — a complex biological secretome of growth factors, exosomes, cytokines, and signaling molecules — delivered through characterized topical formulations across three therapeutic verticals.

Current Products
6
Pipeline Products
6
Verticals
3
Platform
SCCM
Platform
01

What SCCM is — and why the source matters.

Stem Cell Conditioned Media is the biologically active fluid produced by mesenchymal stem cells under defined culture conditions. It contains thousands of bioactive molecules including growth factors, exosomes, and cytokines. Selecting the right stem cell niche and qualified donor source is critical to both therapeutic activity and long-term safety.

Growth Factors

Signaling proteins that participate in tissue-response, inflammation modulation, and cellular recruitment.

Exosomes

Nanoscale extracellular vesicles carrying intercellular signaling cargo across membranes.

Cytokines

Immunomodulatory messengers governing local inflammation and repair dynamics.

Secretome Matrix

The full collective of proteins, lipids, and nucleic acids secreted under defined conditions.

Three Verticals
02

Where the portfolio is focused.

Each vertical addresses a high-demand therapeutic or aesthetic market with clinically observed, cell-free biologics formulated for targeted topical application.

01
Skin Care

Anti-aging, active acne reduction, scar remodeling, and stretch marks — targeting fine lines, hyperpigmentation, and dermal renewal across skin types.

02
Diabetic Pain, Sore & Scar

Therapeutic creams and serums for vascular wounds, bed sores, venous ulcers, diabetic neuropathy, and foot conditioning — conditions with limited effective options today.

03
Hair Management

SCCM serums designed to support follicular regeneration and manage hair growth cycles — a science-backed alternative to conventional restoration.

Current Products
03

Six SCCM formulations in active use.

Formulations with documented protocols and clinical case series. See the Case Studies page for observed outcomes and referenced peer-reviewed publications.

View Case Studies →
Skin Care
01
Wrinkle Cream

Daily topical SCCM serum for fine lines, tone, texture, and elasticity — used alone or paired with microneedling protocols.

Skin Care
02
Acne & Scar Cream

Anti-inflammatory SCCM formulation targeting active acne lesions and post-acne / hypertrophic scar remodeling.

Diabetic Care
03
Diabetic Neuropathy Cream

SCCM topical applied to the feet for symptomatic relief of diabetic peripheral neuropathy — pilot published in Am J Biomed Sci & Res.

Diabetic Care
04
Diabetic Ulcer / Wound Serum

Weekly-application SCCM serum designed to support closure of chronic diabetic wounds and vascular ulcers.

Skin Care
05
Stretch Mark Cream

SCCM formulation aimed at supporting dermal remodeling in striae distensae.

Skin Care
06
Sunburn Damage & Suntan Lotion

SCCM topical for photo-damaged skin — burn-response support and post-exposure recovery.

Development Pipeline
04

Six additional SCCM formulations in development.

Formulations progressing through characterization and process development. Timing subject to regulatory pathway and manufacturing validation.

Wound Care
— P01
Bedsore Serum

SCCM spray + collagen co-treatment for pressure ulcers.

Process in Development
Skin Care
— P02
Cellulite Cream

SCCM formulation targeting sub-dermal connective tissue appearance.

Process in Development
Dermatology
— P03
Eczema Treatment Cream

SCCM formulation for atopic and inflammatory skin conditions.

Process in Development
Hair
— P04
Hair Restoration Serum

Follicular-support SCCM serum used with 0.25–1.0 mm microneedling / dermal stamp protocols.

Process in Development
Diabetic Care
— P05
Foot Conditioning Cream

Maintenance SCCM cream for at-risk diabetic feet — companion to neuropathy and ulcer lines.

Process in Development
Dermatology
— P06
Nail Strengthener Serum

SCCM formulation for weak, brittle, or damaged nails.

Process in Development
Skin Care
5
Formulations across current + pipeline
Diabetic Care
4
Neuropathy, ulcer, foot, bedsore
Hair / Nail
2
Follicular + nail support
Dermatology
1
Eczema pipeline
NoticeProduct descriptions on this page are for scientific and educational purposes. Statements about SCCM composition, mechanism, and observed outcomes are not claims of safety, efficacy, or cleared indications for any specific product. Regulatory pathway, permitted uses, and labeling for each formulation are governed by verified documentation and applicable law. See the Regulatory page for pathway detail.