Exosomes; a Potential Source of Biomarkers, Therapy, and Cure for Type-1 Diabetes
Comprehensive review of exosome biology across biomarker discovery, therapeutic delivery, and disease-modifying strategies in type-1 diabetes. Covers exosome biogenesis, cargo-mediated cellular crosstalk, autoimmune pathways in β-cell dysfunction, and the translational path toward exosome-based diagnostics and therapies, with implications for type-2 diabetes as well.
Comprehensive review of exosome biology across biomarker discovery, therapeutic delivery, and disease-modifying strategies in type-1 diabetes. Covers exosome biogenesis, cargo-mediated cellular crosstalk, autoimmune pathways in β-cell dysfunction, and the translational path toward exosome-based diagnostics and therapies, with implications for type-2 diabetes as well.
Validation of a combinational cryoprotectant strategy using lower-than-conventional concentrations of two permeating agents (DMSO and ethylene glycol) with a stepwise sucrose dilution during recovery. The optimized protocol yielded significantly higher post-thaw MSC viability (~80%) versus conventional DMSO-only approaches, supporting more effective banking of stem cells for downstream therapeutic use.